img#logo {
  height: 3rem;
}

.stats {
  /*font-size: 0.8rem;
  line-height: 1.5em;*/
  text-align: left;

}

footer {
  padding: 0 0;
  background-color: #111;
  margin-top: 5rem;
}

img.footer-logo {
  max-height: 4.5em;
  padding-left: 1em;
}

footer a {
  padding: 0;
}

footer figure.fig {
  margin: 0px;
}

.content {
  max-width: 600em;
  width: 85%;
}


.padtop {
    padding-top: 4rem;
    min-height: 100%;
    /*margin-bottom: 5em;*/
}

.padbottom {
   padding-bottom: 2rem;
}

.newstile {
  box-shadow: 0 0.2rem 1.25rem 0 rgba(27, 30, 36, 0.07);
  padding: 0.3em;
  margin: 0.3em;
}

#cookie-bar {margin: 10px; border-radius:10px; background:#4e4e4e; height:auto; min-height:24px; line-height:24px; color:#eeeeee; text-align:center; padding:3px 0;}
#cookie-bar.fixed {position:fixed; top:0; left:0; width:100%;}
#cookie-bar.fixed.bottom {bottom:0; top:auto;}
#cookie-bar p {margin:0; padding:0;}
#cookie-bar a {color:#ffffff; display:inline-block; border-radius:3px; text-decoration:none; padding:0 6px; margin-left:8px;}
#cookie-bar .cb-enable {background:#007700;}
#cookie-bar .cb-enable:hover {background:#009900;}
#cookie-bar .cb-disable {background:#990000;}
#cookie-bar .cb-disable:hover {background:#bb0000;}
#cookie-bar .cb-policy {background:#0033bb;}
#cookie-bar .cb-policy:hover {background:#0055dd;}


/* GENERAL styles */

span.icon.favorite {
  color: #FFD700;
}

span.icon.not_favorite {
  color: #A9A9A9;
}

div.header-dark div#header-menu div.nav-item li.selected-item a {
  color: var(--cirrus-primary);
}

div#results-quicksearch {
  display: none;
  right : 0;
  top: 4rem;
  position: fixed;
  padding: 1rem;
  z-index: 1;

  color: var(--cirrus-fg);
  background-color: var(--cirrus-bg);
  border-radius: 3px;
  box-shadow: 0 .4rem 1rem rgba(54,54,54,.3);
}

div#modal-quicksearch.modal .modal-overlay {
  background-color: unset;
}

div#showLigand {
  border-radius: 25px;
  position: absolute;
  z-index: 1;
  display: none;
  color: var(--cirrus-fg);
  background-color: var(--cirrus-bg);
  box-shadow: 0 .4rem 1rem rgba(54,54,54,.3);
}

div#showLigand img {
  border-radius: 25px;
}

li.nobullets {
  list-style-type: none;
}

/* NEWS page */

div#newsOverview li a {
  display: inline;
}

div#newsOverview p.card-head-title {
  font-size: 1.35em;
}

div#newsOverview p.card-head-title em {
  margin-left: 0.5em;
  margin-right: 0.5em;
}

div#newsOverview div.card div.content h4 {
  font-size: 1.25em;
}

a.news_anchor {
  top: -70px;
  display: block;
  visibility: hidden;
   position: relative;
}

a.news_index span.news_date {
  color: #868e96;
  width:  7em;
  text-align: right;
  display: inline-block;
}

a.news_index span.news_title {
  padding-left:  1em;
  color: var(--cirrus-fg);
  display: inline-block; 
}

/* KINOME displaying main page */
canvas#kinome {
  z-index: 0;
  /*position: absolute;
  left : 0;
  top : 0;*/
  background-color: white;
}

canvas#kinomeoverlay {
  z-index: 1;
  position: absolute;
  /*left : 0px;
  top : 0px;*/
}

/* KINOME displaying search page */
div#kinome-modal div.modal-body{
  max-height: 80vh;
}

span.drug_label, span.hit_label {
  position: absolute;
  margin-left: 1rem;
  font-weight: bold;
}

img.drug_reference {
  margin-top: 0.5em;
}

/* BROWSE page */

table#browseList, table#searchResults {
  display: none;
}

table#browseList i.fa-download, table#searchResults i.fa-download {
  color: #FD7E14;
}

/* FAVORITES */
div.card-image.center-image {
  background-position: center;
}

div.favorite_card span.icon i.fa-wrapper {
  font-size: 1.5em;
}

div.no_favorites i {
  font-size: 2em;
}

/* SEARCH page */

table#structurePropertiesSearch,  table#ligandPropertiesSearch, table#structureConformationSearch {
  border-spacing: 0em 0.8em;
}

table#structurePropertiesSearch tr, table#ligandPropertiesSearch tr, table#structureConformationSearch tr {
  line-height: 1em;
}

div.divider.search {
  margin-top: 5em;
  /*margin-bottom: 5em;*/
}

div.tooltipster_title {
  font-weight: bold;
  margin-bottom: 0.3em;
}

div.tooltipster_body {
  
}

div#item_search_kinase_classification{
  margin-top: 3.5em;
}

div#searchSlider {
  overflow-y: auto;
  overflow-x: hidden;
  height: 72vh;
}

table.residueSearch {
    /*width: 100%;*/
    width: 97%;
}

table.residueSearch tr td {
    text-align: center;
    width: 5%;
}

div#searchSlider table.residueSearch select {
  background-color: #ddd;
  -webkit-appearance: none;
  -moz-appearance: none;
  appearance: none;
  text-align: center;
  padding: 10% 0 10% 35%;
  font-weight: bold;
}

button#searchStart {
  margin-top: 2em;
  margin-left: auto;
  margin-right: auto;
}

div.watercontainer {
  margin-right: 0.5em;
}

div.watercluster {
  text-align: center;
}

div.search_tag_item, div.detail_tag_item {
  min-height: 70vh;
  margin-left: 3%;
}

div#item_detail_general_information {
  min-height: 30vh;
}

div.search_tag_item tr td:first-child {
  padding-right: 1em;
}

div#item_search_structure_sequence tr td:first-child, div#item_search_ligand_interactions tr td:first-child {
  padding-right: 0em;
}

div.aloop_wrapper, div.achelix_wrapper {
  margin-top: 1em;
}

div#slider-aloop, div#slider-achelix {
  margin-top: 0.5em;
  margin-left: 1em;
  margin-right: 1em;
}

div#searchSlider select {
  padding: 0.4em;
}

/* 85 residues coloring for tables */

/* TOFIX create css colors for KLIFS */
body.orig_scheme table.residueSearch tr td.sheets, table.residueSearch tr td.sheets {
    font-weight: bold;
    background-color: #F8F66C;
}

body.orig_scheme table.residueSearch tr td.grich, table.residueSearch tr td.grich {
    font-weight: bold;
    background-color: #4CD43D;
}

body.orig_scheme table.residueSearch tr td.helices, table.residueSearch tr td.helices {
    font-weight: bold;
    background-color: #F27272;
}

body.orig_scheme table.residueSearch tr td.gatekeeper, table.residueSearch tr td.gatekeeper {
    font-weight: bold;
    background-color: #FFD000;
}

body.orig_scheme table.residueSearch tr td.hinge, table.residueSearch tr td.hinge {
    font-weight: bold;
    background-color: #FF75FD;
}

body.orig_scheme table.residueSearch tr td.linker, table.residueSearch tr td.linker {
    font-weight: bold;
    background-color: #00FFFF;
}

body.orig_scheme table.residueSearch tr td.catalytic, table.residueSearch tr td.catalytic {
    font-weight: bold;
    background-color: #FFA600;
}

body.orig_scheme table.residueSearch tr td.activation, table.residueSearch tr td.activation {
    font-weight: bold;
    background-color: #6698FF;
}

/* Paul Tol - color scheme */
body.tol_scheme table.residueSearch tr td.sheets {
    font-weight: bold;
    background-color: #EEDD88;
}

body.tol_scheme table.residueSearch tr td.grich {
  font-weight: bold;
    background-color: #228833;
    color: #FFF;
}

body.tol_scheme table.residueSearch tr td.helices {
  font-weight: bold;
    background-color: #EE6677;
}

body.tol_scheme table.residueSearch tr td.gatekeeper {
  font-weight: bold;
    background-color: #CCBB44;
}

body.tol_scheme table.residueSearch tr td.hinge {
  font-weight: bold;
    background-color: #882255;
    color: #FFF;
}

body.tol_scheme table.residueSearch tr td.linker {
  font-weight: bold;
    background-color: #66CCEE;
}

body.tol_scheme table.residueSearch tr td.catalytic {
  font-weight: bold;
    background-color: #000000;
    color: #FFF;
}

body.tol_scheme table.residueSearch tr td.activation {
  font-weight: bold;
    background-color: #0077BB;
    color: #FFF;
}

body.tol_scheme .text-success {
  color: #DDAA33!important;
}

body.tol_scheme .text-danger {
  color: #004488!important;
}


/*table.residueSearch span.xray {
    font-size: 0.8em;
    font-style:italic;
}

table.residueSearch span.mutated {
    color: red;
    font-weight: bold;
}

td.residueSearchHeader {
    font-weight: bold;
}

td.residueSearch {
    border-right: 1px solid #FFF6D1;
    border-left: 1px solid #FFF6D1;
}

td.residueSearchBottom {
    border-right: 1px solid #FFF6D1;
    border-left: 1px solid #FFF6D1;
    border-bottom: 1px solid #FFF6D1;
}*/

/*
table.tablesorter {
    font-family:arial;
    background-color: #CDCDCD;*/
/*    margin:10px 0pt 15px;
    font-size: 8pt;*/
/*    margin: 0.5em 0px 1em;
    font-size: 0.75em;
    width: 100%;
    text-align: center;
}*/

/* DETAIL page */

div#detailSlider {
  overflow-y: auto;
  overflow-x: hidden;
  height: 72vh;
}

div.container-wrapper {
  position: relative;
}

td.detailInfo, td.detailName {
  white-space: nowrap;
}

span.icon_toggles {
  margin-left: 0.5em;
}

span#ngl_toggle {
  margin-left: 2em;
}

h5.detail_title {
  margin-top: 1em;
}

div#detailsMenu h3 {
  margin: 0;
}

table.pockets h4 {
  margin: 0;
}

table.pocketSequence {
  font-family: monospace;
  font-size: 1.2em;
}

canvas#kinase_fold {
  border: 1px solid darkgray;
}

div#foldOptions li.head, div#foldOptions li.head:hover {
  background-color: var(--cirrus-gray);
}

div#downloadMenu, div#foldOptions {
  font-size: 0.9em;
  position: absolute;
  display: none;
  -webkit-transform: translateX(-80%);
  -moz-transform: translateX(-80%);
  transform: translateX(-80%);
  box-shadow: 0 4px 8px 0 rgba(0, 0, 0, 0.2), 0 6px 20px 0 rgba(0, 0, 0, 0.19);
  z-index: 10;
}

div#downloadMenu, div#foldOptions {
  display: : block;
}

div#downloadMenu ul, div#foldOptions ul {
  margin: 0px;
  padding-inline-start: 0px;
}

div#downloadMenu a, div#foldOptions a {
  color:inherit;
  text-decoration: none;
 }

div#downloadMenu li, div#foldOptions li {
    list-style-type:none;
    padding: 0.5rem 1rem;
    margin: 0;
    white-space: nowrap;
    background-color: #fff;
}

div#downloadMenu li:hover, div#foldOptions li:hover {
    background-color: #f03d4d;
}

div.watercontainer {
  margin: 0.5em;
  padding: 0.25em;
}

div#viewport {
  position: relative;
  display: block;
}

table.chemblDetails {
  font-size: 0.9em;
  white-space: normal;
}

table.chemblDetails thead th {
    position: sticky;
    position: -webkit-sticky;
    top: 0;
    background-color: white;
}

div.chemblContainer {
  overflow: auto;
  max-height: 60vh;
  max-width: 97%;
}

button.other_entries {
  margin-right: 0.5em;
}

div#IFP-coding {
    text-align: center;
}

span.ifp {
    font-size: 1em;
}

span.hyd {
    color: #888888;
    font-size: 0.9em;
}

span.aff {
    color: #006600;
}

span.afe {
    color: #4CD43D;
}

span.don {
    color: #FF0000;
}

span.acc {
    color: #3A33FF;
}

span.ionpos {
    color: #EE7600;
}

span.ionneg {
    color: #00CCCC;
}


/* Paul Tol - color scheme interactions */
body.tol_scheme span.hyd {
    color: #888888;
}

body.tol_scheme span.aff {
    color: #006600;
}

body.tol_scheme span.afe {
    color: #4CD43D;
}

body.tol_scheme span.don {
    color: #FF0000;
}

body.tol_scheme span.acc {
    color: #3A33FF;
}

body.tol_scheme span.ionpos {
    color: #EE7600;
}

body.tol_scheme span.ionneg {
    color: #00CCCC;
}

/* FAQ styles */
div.faq-logos div.col-fluid {
  margin: 0.5em;
}


div.faq-logos div.col-fluid a {
  position: relative;
  /*height: 100%;*/
  height: 12vh;
}

div.FAQbrand {
  /*position: absolute;*/
  text-align: center;
  bottom: 0;
}

div.FAQlogo img {
    height: 7vh;
}

div.FAQlogo h2 {
  margin: 0;
  height: 7vh;
}

div.faqs div.card {
  width: 100%;
}

img.FAQimage {
  max-height: 50vh;
}

img#human_image {
  padding: 0.25em;
  border: 1px solid gray;
}

/* DRUGS */
div.drugs blockquote {
  margin: 0;
  margin-bottom: 1rem;
  padding: 0.2rem 1rem;
  font-size: 1.1rem;
}

div#druglist_wrapper {
  top: -2rem;
  width: 100%;
}

table#druglist {
  width: 100%;
}



/* RADIAL RANGE SELECTOR */
input.circle-range-select {
     display: none;
}
 .circle-range-select-wrapper {
     position: relative;
     max-width: 100%;
     width: 10em;
     height: 10em;
     margin: 1em;
     padding: 0.65em !important;
     border-radius: 50%;
     border: 0.4em solid #ccc;
     cursor: default;
}
 .circle-range-select-wrapper .handle {
     position: absolute;
     z-index: 2;
     width: 0;
     height: 0;
     border: 0;
     padding: 0;
     cursor: pointer;
}
 .circle-range-select-wrapper .handle:before {
     content: '';
     position: absolute;
     z-index: 3;
     top: -0.65em;
     left: -0.65em;
     height: 1.3em;
     width: 1.3em;
     border-radius: 50%;
     border: 0.1em solid #000;
     /*background: #000;*/
}

.circle-range-select-wrapper .handle1:before {
  background: #3a3;
}

.circle-range-select-wrapper .handle2:before {
  background: #a33;
}

 .circle-range-select-wrapper .selected-range {
     position: absolute;
     z-index: 1;
     /*color: #0F0;*/
     color: #f03d4d;
}
 .circle-range-select-wrapper .values {
     pointer-events: none;
     position: absolute;
     z-index: 2;
     top: 24%;
     left: 0;
     right: 0;
     margin-top: -0.5em;
     font-family: "Courier New", Courier, "Lucida Sans Typewriter", "Lucida Typewriter", monospace; 
     font-size: 1.4em;
     font-weight: bold;
     text-align: center;
}
 
div.reset_rotation {
  margin-top: 0.5em;
}

/* NoUIslider - Cirrus coloring */
div#searchSlider div.noUi-connect {
  background: #f03d4d;
}

div.aloop_wrapper, div.achelix_wrapper {
  background-size: contain;
  /*width: 100%;*/
  width: 13em;
  height: 0;
  padding-bottom: 70%;
  border: 1px solid lightgray;
  border-radius: 5%;
}

div.aloop_wrapper {
  background-image: url('/images/DFG_aloop_movement.png'); 
}

div.achelix_wrapper {
  background-image: url('/images/AChelix_movement.png'); 
}


div#slider-aloop .noUi-tooltip, div#slider-achelix .noUi-tooltip {
    -webkit-transform: translate(-50%,0);
    transform: translate(-50%,0);
    left: 50%;
    bottom: -180%;
}

div#cookie_settings {
  width: 30em;
}

div#cookie_settings label span {
  /*width: 30em;*/
  font-weight:  bold;
}